Listed here are selected scientific publications authored or co-authored by staff scientists at the Center for Neurosciences at The Feinstein Institute for Medical Research.

Publications are grouped by disease category, and further subdivided into two listings: Original Articles and Chapters, Reviews and Editorials.

The disease categories are as follows:

Parkinson’s Disease, Selected Publications, 2008–present


Original Articles
  1. Hirano S, Asanuma K, Ma Y, Tang C, Feigin A, Dhawan V, Carbon M, Eidelberg D. Dissociation of metabolic and neurovascular responses to levodopa in the treatment of Parkinson’s disease. J Neurosci, 2008; 28(16):4201-9 [PMC 2577921]
  2. Eckert T, Tang C, Ma Y, Brown N, Lin T, Frucht S, Feigin A, Eidelberg D. Abnormal metabolic networks in atypical parkinsonism. Mov Disord, 2008; 23(5):727-33
  3. Huang C, Mattis P, Perrine K, Brown N, Dhawan V, Eidelberg D. Metabolic abnormalities associated with mild cognitive impairment in Parkinson’s disease. Neurology, 2008; 70(16 Pt 2):1470-7
  4. Lin T, Carbon M, Tang C, Mogilner A, Sterio D, Beric A, Dhawan V, Eidelberg D. Metabolic correlates of subthalamic nucleus activity in Parkinson’s disease. Brain, 2008; 131(Pt 5):1373-80
  5. Louis ED, Pullman S, Eidelberg D, Dhawan V. Re-emergent tremor without accompanying rest tremor in Parkinson’s disease. Can J Neurol Sci, 2008; 35(4):513-5
  6. Argyelan M, Carbon M, Ghilardi MF, Feigin A, Mattis P, Dhawan V, Eidelberg D. Dopaminergic suppression of brain deactivation responses during sequence learning. J Neurosci, 2008; 28(42):10687-95.
  7. Marinelli L, Crupi D, DiRocco A, Bove M, Eidelberg D, Abbruzzese G, Ghilardi MF. Learning and consolidation of visuo-motor adaptation in Parkinson’s disease. Parkinsonism Rel Disord, 2009; 15(1): 6-11 [PMC 2656368]
  8. Pourfar M, Tang C, Lin T, Dhawan V, Kaplitt M, Eidelberg D. Assessing the microlesion effect of subthalamic deep brain stimulation surgery with FDG PET. J Neurosurg, 2009; 110(6):1278-82
  9. Carbon M, Reetz K, Ghilardi MF, Dhawan V, Eidelberg D. Early Parkinson’s disease: Longitudinal changes in brain activity during sequence learning. Neurobiol Dis, 2010; 37(2)455-60 [PMC 2818462]
  10. Tang C, Poston K, Dhawan V, Eidelberg D. Abnormalities in metabolic network activity precede the onset of motor symptoms in Parkinson’s disease. J Neurosci, 2010; 30(3):1049-56 [PMC 2866050]
  11. Ma Y, Tang C, Chaly T, Greene P, Breeze R, Fahn S, Freed C, Dhawan V, Eidelberg D. Dopamine cell implantation in Parkinson’s disease: long-term clinical and 18F-FDOPA PET outcomes. J Nucl Med, 2010; 51:7-15 [PMC 2946843]
  12. Tang C, Poston K, Eckert T, Feigin A, Frucht S, Gudesblatt M, Dhawan V, Lesser M, Vonsattel J-P, Fahn S, Eidelberg D. Differential diagnosis of parkinsonism: a metabolic imaging study using pattern analysis. Lancet Neurol, 2010; 9(2):149-58 [NIHMS 174570]
  13. Marinelli L, Perfetti B, Moisello C, Di Rocco A, Eidelberg D, Abbruzzese G, Ghilardi MF. Increased reaction time predicts visual learning deficits in Parkinson’s disease. Mov Disord, 2010; 25(10):1498-501 [PMC 3124249]
  14. Mure H, Hirano S, Tang CC, Isaias IU, Antonini A, Ma Y, Dhawan V, Eidelberg D. Parkinson’s disease tremor-related metabolic network: characterization, progression, and treatment effects. NeuroImage, 2011; 54(2):1244-53 [PMC 2997135]
  15. Mattis PJ, Tang CC, Ma Y, Dhawan V, Eidelberg D. Network correlates of the cognitive response to levodopa in Parkinson’s disease. Neurology, 2011; 77:858-65 [PMC 3162641]
  16. Sidtis J, Tagliati M, Alterman R, Sidtis D, Dhawan V, Eidelberg D. Therapeutic high frequency stimulation of the subthalamic nucleus in Parkinson’s disease produces global increases in cerebral blood flow. J Cereb Blood Flow Metab, 2012; 32(1):41-9 [PMC 3323302]
  17. Pourfar MH, Tang CC, Mogilner AY, Dhawan V, Eidelberg D. Using imaging to identify psychogenic parkinsonism before deep brain stimulation surgery. J Neurosurg, 2012;116(1):114-8
  18. Ma Y, Peng S, Spetsieris PG, Sossi V, Eidelberg D, Doudet DJ. Abnormal metabolic brain networks in a nonhuman primate model of parkinsonism. J Cereb Blood Flow Metab, 2012; 32: 633-42 [PMC 3318142]
  19. Mure H, Tang CC, Argyelan M, Ghilardi MF, Kaplitt MG, Dhawan V, Eidelberg D. Improved sequence learning with subthalamic nucleus deep brain stimulation: evidence for treatment-specific network modulation. J Neurosci, 2012; 32(8):2804-13.
  20. Ko JH, Mure H, Tang CC, Ma Yilong, Dhawan V, Spetsieris PG, Eidelberg D. Parkinson’s disease: Increased motor network activity in the absence of movement. J Neurosci, 2013; 33(10): 4540-9 [PMC 3671574]
  21. Niethammer M, Tang CC, Ma Y, Mattis PJ, Ko JH, Dhawan V, Eidelberg D. Parkinson’s disease cognitive network correlates with caudate dopamine. NeuroImage, 2013; 78:204-9 [PMC 3672243]
Chapters, Reviews, and Editorials
  1. Pourfar M, Feigin A, Eidelberg D. The natural history of Parkinson’s disease. In: Parkinson’s disease: diagnosis and clinical management, second edition. SA Factor and WJ Weiner, editors. New York: Demos Medical Publishing, Inc.; 2008:127-33
  2. Hirano S, Eckert T, Flanagan T, Eidelberg D. Metabolic networks for assessment of therapy and diagnosis in Parkinson’s disease. Mov Disord, 2009;24 (S2):S725-31
  3. Mattis P, Eidelberg D. Imaging cognition and Parkinson’s disease: An overview. US Neurol, 2010; 5(2):26-9
  4. Poston K, Eidelberg D. FDG PET in the evaluation of Parkinson’s disease. In: PET in the Aging Brain, An Issue of PET Clinics (The Clinics: Radiology). Newberg A, editor. Saunders; 2010; 5(1):55-64
  5. Fitzpatrick T, Mattis P, Eidelberg D. Functional imaging of cognitive impairment in Parkinson’s disease. Clin EEG Neurosci, 2010; 41(3):119-26
  6. Tang CC, Eidelberg D. Abnormal metabolic brain networks in Parkinson’s disease: from blackboard to bedside. Prog Brain Res, 2010; 184:161-76
  7. Imaging in Parkinson’s disease. Eidelberg D, editor. New York: Oxford University Press; 2011 [Book]
  8. Ma Y, Peng S, Dhawan V, Eidelberg D. Dopamine cell transplantation in Parkinson’s disease: challenge and perspective. Br Med Bull, 2011; 100:173-89 [PMC 3276236]
  9. Niethammer M, Feigin A, Eidelberg D. Functional neuroimaging in Parkinson’s disease. Cold Spring Harb Perspect Med, 2012; 2(5): a009274 [Review] [PMC 3331691]
  10. Hirano S, Shinotoh H, Eidelberg D. Functional brain imaging of cognitive dysfunction in Parkinson’s disease. J Neurol Neurosurg Psychiatry, 2012; 83(10):963-9

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Huntington’s Disease, Selected Publications, 1998–present


Original Articles
  1. Antonini A, Leenders KL, Eidelberg D. [11C]-Raclopride-PET studies of the Huntington’s disease rate of progression: Relevance of the trinucleotide repeat length. Ann Neurol, 1998; 43:253-5
  2. Feigin A, Leenders KL, Moeller JR, Missimer J, Kuenig G, Spetsieris P, Antonini A, Eidelberg D. Metabolic network abnormalities in early Huntington’s disease: An [18F] FDG PET study. J Nucl Med, 2001; 42:1591-5
  3. Feigin A, Ghilardi MF, Huang C, Ma Y, Carbon M, Guttman M, Paulsen JS, Ghez CP, Eidelberg D. Preclinical Huntington’s disease: Compensatory brain responses during learning. Ann Neurol, 2006; 59(1):53-9 [PMC 2519955]
  4. Feigin A, Tang C, Ma Y, Mattis P, Zgaljardic D, Guttman M, Paulsen JS, Dhawan V, Eidelberg D. Thalamic metabolism and symptom onset in preclinical Huntington’s disease. Brain, 2007; 130(Pt 11):2858-67 [NIHMS 57763]
  5. Tang C, Feigin A, Ma Y, Habeck C, Paulsen JS, Teune LK, Leenders KL, Guttman M, Dhawan V. Metabolic network activity as a progression biomarker of premanifest Huntington’s disease. J Clin Invest, 2013; in press
Chapters, Reviews, and Editorials
  1. Eidelberg D. Brain networks and clinical penetrance: Lessons from hyperkinetic movement disorders. Curr Opin Neurol, 2003; 16(4):471-474
  2. Ma Y, Eidelberg D. Functional imaging of cerebral blood flow and glucose metabolism in Parkinson’s disease and Huntington’s disease. Mol Imag Biol, 2007; 9(4):223-33
  3. Ghilardi MF, Silvestri G, Feigin A, Mattis P, Zgaljardic D, Moisello C, Crupi D, Marinelli L, Di Rocco A, Eidelberg D. Implicit and explicit aspects of sequence learning in presymptomatic Huntington’s disease. Parkinsonism Relat Disord, 2008; 14(6):457-64 [PMC 2562166]
  4. Eidelberg D, Surmeier DJ. Brain networks in Huntington’s disease. J Clin Invest, 2011; 121(2):484-92 [PMC 3026742]

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Dystonia, Selected Publications, 2008–present


 Original Articles
  1. Carbon M, Ghilardi M-F, Argyelan M, Dhawan V, Bressman S, Eidelberg D. Increased cerebellar activation during sequence learning in DYT1 carriers: An equiperformance study. Brain, 2008; 131(1):146-54
  2. Carbon M, Kingsley PB, Tang C, Bressman S, Eidelberg D. Microstructural white matter changes in primary torsion dystonia. Mov Disord, 2008; 23(2):234-9
  3. Carbon M, Niethammer M, Peng S, Raymond D, Dhawan V, Chaly T, Ma Y, Bressman S, Eidelberg D. Abnormal striatal and thalamic dopamine neurotransmission: genotype-related features of dystonia. Neurology, 2009; 72(24):2097-103 [PMC 2760608]
  4. Argyelan M, Carbon M, Niethammer M, Ulug AM, Henning UV, Bressman SB, Dhawan V, Eidelberg D. Cerebello-thalamo-cortical connectivity regulates penetrance in dystonia. J Neurosci, 2009; 29(31):9740-7 [PMC 2745646]
  5. Carbon M, Argyelan M, Habeck C, Ghilardi MF, Fitzpatrick T, Dhawan V, Pourfar M, Bressman SB, Eidelberg D. Increased sensorimotor network activity in DYT1 dystonia: A functional imaging study. Brain, 2010; 133(Pt 3):690-700 [PMC 2842516]
  6. Ulug AM, Vo A, Argyelan M, Tanabe L, Schiffer WK, Dewey S, Dauer WT, Eidelberg D. Selective motor system abnormalities in DYT1 mutant TorsinA knock-in mice. Proc Natl Acad Sci USA, 2011; 108(16):6638-43 [PMC 3081027]
  7. Carbon M, Argyelan M, Ghilardi M.F., Mattis P, Dhawan V, Bressman S, Eidelberg D. Impaired sequence learning in dystonia mutation carriers: a genotypic effect. Brain, 2011; 134(Pt 5):1416-27 [PMC 3097890]
  8. Vo A, Eidelberg D, Uluğ AM. White matter changes in primary torsion dystonia determined by 2-D distribution analysis of diffusion tensor images. J Magn Reson Imaging, 2013; 37(1):59-66
  9. Vo A, Argyelan M, Eidelberg D, Uluğ AM. Early registration of diffusion tensor images for group tractography of dystonia patients. J Magn Reson Imaging, 2013; 37(1):67-75
  10. Carbon M, Raymond D, Ozelius L, Saunders-Pullman R, Frucht S, Dhawan V, Bressman S, Eidelberg D. Metabolic changes in DYT11 myoclonus-dystonia. Neurology, 2013; 80(4):385-91 [PMC 3589244]
Chapters, Reviews, and Editorials
  1. Carbon M, Eidelberg D. Abnormal structure-function relationships in hereditary dystonia. Neuroscience, 2009; 164:220-9 [PMC 2760608]
  2. Carbon M, Argyelan M, Eidelberg D. Functional imaging in hereditary dystonia. Eur J Neurol, 2010;17(Suppl 1):58-64 [NIMHS 226143]
  3. Niethammer M, Carbon M, Argyelan M, Eidelberg D. Hereditary dystonia as a neurodevelopmental circuit disorder: evidence from neuroimaging. Neurobiol Dis, 2011; 42(2):202-9 [PMC 2997135]

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Movement Disorders, Selected Publications, 2008–present


 Original Articles
  1. Eckert T, Tang C, Ma Y, Brown N, Lin T, Frucht S, Feigin A, Eidelberg D. Abnormal metabolic networks in atypical parkinsonism. Mov Disord, 2008; 23(5):727-33
  2. Isaias IU, Marotta G, Hirano S, Canesi M, Benti R, Righini A, Cilia R, Pezzoli G, Eidelberg D, Antonini A. Imaging essential tremor. Mov Disord, 2010; 25(6):679-86
  3. Pourfar M, Feigin A, Tang CC, Carbon-Correll M, Bussa M, Budman C, Dhawan V, Eidelberg D. Abnormal metabolic brain networks in Tourette syndrome. Neurology, 2011; 76(11):944-52 [PMC3271575]
  4. Poston KL, Eidelberg D. Functional brain networks and abnormal connectivity in the movement disorders. Neuroimage, 2011; 62(4): 2261-70 [Review] [PMC 3489159]
  5. Holtbernd F, Eidelberg D. Functional brain networks in movement disorders: recent advances. Curr Opin Neurol, 2012; 25(4):392-401 [Review]
  6. Poston KL, Tang CC, Eckert T, Dhawan V, Frucht S, Vonsattel JP, Fahn S, Eidelberg D. Network correlates of disease severity in multiple system atrophy. Neurology, 2012; 78(16): 1237-44 [PMC 3324319]
  7. Barrett MJ, Hagenah J, Dhawan V, Peng S, Stanley K, Raymond D, Deik A, Gross SJ, Schreiber-Agus N, Mirelman A, Marder K, Ozelius LJ, Eidelberg D, Bressman SB, Saunders-Pullman R; The LRRK2 Ashkenazi Jewish Consortium. Transcranial sonography and functional imaging in glucocerebrosidase mutation Parkinson disease. Parkinsonism Relat Disord, 2013; 19(2):186-91
  8. Asanuma K, Dhawan V, Carbon M, Eidelberg D. Assessment of disease progression in parkinsonism. J Neurol, 2004; 251(7):4-8
Chapters, Reviews, and Editorials
  1. Pourfar M, Eidelberg D. Movement disorders. In: The Merck Manual: Home Edition. New Jersey: Merck & Co., Inc.; 2008: 544-5
  2. Poston KL, Eidelberg D. Network biomarkers for the diagnosis and treatment of movement disorders. Neurobiol Dis, 2009; 35:141-7
  3. Poston KL and Eidelberg D. Functional brain networks and abnormal connectivity in the movement disorders. NeuroImage, 2012; 62(4): 2261-70
  4. Holtbernd F and Eidelberg D. Functional brain networks in movement disorders – recent advances. Curr Opin Neurol, 2012; 25(4):392-401
  5. Niethammer M, Eidelberg D. Neuroimaging studies in the evaluation of patients with movement disorders. Neuroimaging Studies, Chapter 3. In: Tremor, Parkinson’s Disease and Related Movement Disorders, LeWitt PA, editor; Cambridge University Press, in press

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Brain Imaging in Neurodegenerative Disorders, Selected Publications, 2008–present


 Original Articles
  1. Spetsieris P, Ma Y, Dhawan V, Eidelberg D. Differential diagnosis of parkinsonian syndromes using functional PCA-based imaging features. NeuroImage, 2009; 45(4):1241-52
  2. Ma Y, Tang C, Moeller J, Eidelberg D. Abnormal regional brain function in Parkinson’s disease: Truth or fiction? NeuroImage, 2009; 45(2): 260-6 [PMC 2946847]
  3. Eidelberg D. Metabolic brain networks in neurodegenerative disorders: a functional imaging approach. Trends Neurosci, 2009; 32(10):548-57
  4. Spetsieris PG, Dhawan V, Eidelberg D. Three-fold cross-validation of parkinsonian brain patterns. Conf Proc IEEE Eng Med Biol Soc, 2010; 1:2906-09
  5. Moisello C, Perfetti B, Marinelli L, Sanguineti V, Bove M, Feigin A, DiRocco A, Eidelberg D, Felice Ghilardi M. Basal ganglia and kinematics modulation: insights from Parkinson’s and Huntington’s diseases. Parkinsonism Relat Disord, 2011; 17(8):642-44
  6. Spetsieris PG, Eidelberg D. Scaled subprofile modeling of resting state imaging data in Parkinson’s disease: methodological issues. NeuroImage, 2011; 54:2899-914 [PMC 3020239]
  7. Dhawan V, Tang CC, Ma Y, Spetsieris P, Eidelberg D. Abnormal network topographies and changes in global activity: absence of a causal relationship. NeuroImage, 2012; 63(4):1827-32 [PMC 3474325]
  8. Niethammer M, Eidelberg D. Metabolic brain networks in translational neurology: concepts and applications. Ann Neurol, 2012; 72(5):635-47 [Review]
  9. Perlmutter JS, Eidelberg D. To scan or not to scan: DaT is the question. Neurology, 2012; 78: 688-9. [Editorial]
  10. Peng S, Ma Y, Spetsieris PG, Mattis P, Feigin A, Dhawan V, Eidelberg D. Characterization of disease-related covariance topographies with SSMPCA toolbox: effects of spatial normalization and PET scanners. Hum Brain Mapp, 2013; May 14; [Epub ahead of print]
  11. Spetsieris P, Ma Y, Peng S, Ko JH, Dhawan V, Tang CC, Eidelberg D. Identification of disease-related spatial covariance patterns using neuroimaging data. J Vis Exp, 2013; 76:e50319
    [You can watch the video of this article below. If you’re using Firefox, though, please try viewing it on another browser; we’re trying to fix the problem as soon as possible. If your institution subscribes to J Vis Exp, you can also click on the following link: http://www.jove.com/video/50319]

    Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Chapters, Reviews, and Editorials
  1. Dhawan V, Eidelberg D. Positron emission tomography imaging. Front Neurol Neurosci, 2009; 25:197-202
  2. Stoessl AJ, Brooks DJ, Eidelberg D. Milestones in Neuroimaging. Mov Disord, 2011;26(6):968-78
  3. Perlmutter JS and Eidelberg D. To scan or not to scan: DaT is the question. Neurology, 2012; 78(10):688-9 [Editorial]
  4. Ko JH, Tang CC, Eidelberg D. Brain stimulation and functional imaging with fMRI and PET. Section 1, Chapter 8. In: Handbook of Clinical Neurology: Brain Stimulation, Lozano A and Hallett M, editors; Elsevier, 2013

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Other, Selected Publications, 2008–present


 Original Articles
  1. Sevy S, Smith G, Ma Y, Dhawan V, Chaly T, Kingsley P, Kumra S, Abdelmessih S, Eidelberg D. Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. Psychopharmacology (Berl), 2008;197(4):549-56
  2. Smith, G, Ma, Y, Dhawan, V, Chaly, T, Eidelberg, D. Selective Serotonin Reuptake Inhibitor (SSRI) modulation of striatal dopamine measured with [11C]-raclopride and positron emission tomography (PET). Synapse, 2009; 63(1):1-6
  3. Smith G, Kramer E, Ma Y, Hermann C, Dhawan V, Chaly T, Eidelberg D. Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer’s disease. Brain, 2009; 132(2): 392-401 [PMC 2640217]
  4. Mehta A, Ettinger AB, Perrine K, Dhawan V, Patil A, Jain SK, Klein G, Schneider SJ, Eidelberg D. Seizure propagation in a patient with musicogenic epilepsy. Epilepsy Behav, 2009; 14(2): 421-4
  5. Smith G, Kramer E, Hermann C, Ma Y, Dhawan V, Chaly T, Eidelberg D. The functional neuroanatomy of geriatric depression. Int J Geriatr Psychiatry, 2009; 24(8):798-808 [PMC 2730507]
  6. Smith G, Kramer E, Hermann C, Ma Y, Dhawan V, Chaly T, Eidelberg D. Serotonin modulation of cerebral glucose metabolism in geriatric depression. Biol Psychiatry, 2009; 66(3):259-66
  7. Smith GS, Workman CI, Kramer E, Hermann CR, Ginsberg R, Ma Y, Dhawan V, Chaly T, Eidelberg D. The relationship between the acute cerebral metabolic response to citalopram and chronic citalopram treatment outcome. Am J Geriatr Psychiatry, 2011; 19(1):53-63
  8. Diaconescu AO, Kramer E, Hermann C, Ma Y, Dhawan V, Chaly T, Eidelberg D, McIntosh AR, Smith GS. Distinct functional networks associated with improvement of affective symptoms and cognitive function during citalopram treatment in geriatric depression. Hum Brain Mapp, 2011; 32(10):1677-91
  9. Mackay M, Bussa MP, Aranow C, Uluğ AM, Volpe BT, Huerta PT, Argyelan M, Mandel A, Hirsch J, Diamond B, Eidelberg D. Differences in regional brain activation patterns assessed by functional magnetic resonance imaging in patients with Systemic Lupus Erythematosus stratified by disease duration. Mol Med, 2011; 17(11-12): 1349-56 [PMC 3321819]
  10. Duty B, Andonian S, Ma Y, Peng S, Shapiro E, Dhawan V, Richstone L, Eidelberg D, Kavoussi LR. Laparoscopic experience correlates with differential functional brain activation: a positron emission tomography scan study with oxygen-15 labeled water. Arch Surg, 2012; 147(7):627-32
  11. Munro CA, Workman C, Kramer E, Hermann C, Ma Y, Dhawan V, Chaly T, Eidelberg D, Smith GS. Serotonin modulation of cerebral glucose metabolism: sex and age effects. Synapse, 2012; 66(11):955-64
  12. Marano CM, Workman CI, Kramer E, Hermann CR, Ma Y, Dhawan V, Chaly T, Eidelberg D, Smith GS. Longitudinal studies of cerebral glucose metabolism in late-life depression and normal aging. Int J Geriatr Psychiatry, 2012; Jun 27 [Epub ahead of print]
Chapters, Reviews, and Editorials
  1. Dhawan V, Eidelberg D. Mom and me: brain metabolism links Alzheimer’s disease to maternal genes. Neurology, 2009; 72(6):486-7 [Editorial]
  2. Niethammer M and Eidelberg D. Metabolic brain networks in translational neurology: concepts and applications. Ann Neurol, (Neurological Progress), 2012; 72(5):635-47
  3. Eidelberg D, Martin W. Different beta-amyloid binding patterns in Alzheimer and Parkinson disease: it’s the network! Neurology, 2013; Jul 3 [Epub ahead of print]

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